A New 23andMe+ Report on HDL Cholesterol

Not all ldl cholesterol is created equal. Understanding the distinction between “good” and “unhealthy” ldl cholesterol, in addition to your levels of cholesterol, might help in your quest for a wholesome coronary heart. 

The Good, the Unhealthy, and the Gunky

Coronary heart illness is a leading cause of death in the US. Coronary artery illness is the commonest kind of coronary heart illness in the US. It’s characterised by a build-up of a waxy, cholesterol-containing plaque that narrows the arteries and reduces blood circulation, impacting the center’s rhythm, the center muscle groups, and the opposite blood vessels related to it.  

The gunky build-up of plaque is the place so-called “good” and “unhealthy” ldl cholesterol come into play. Excessive ranges of low-density lipoprotein, or LDL, the so-called “unhealthy ldl cholesterol,” are related to the next threat for coronary heart illness. Increased ranges of high-density lipoprotein, or HDL, the so-called “good ldl cholesterol,” are related to a decrease threat for coronary heart illness. That’s as a result of HDL acts like an arterial cleanser, eradicating ldl cholesterol from blood vessels and taking it again to the liver for its elimination from the physique. This helps stop LDL ldl cholesterol from build up on the partitions of blood vessels and limiting blood circulation.

Sometimes, you’ll be able to find out about your levels of cholesterol via a fasting blood check that features a lipid profile. This usually consists of measurements of complete ldl cholesterol, triglyceride ranges, in addition to LDL and HDL ranges. Many exams additionally take a look at the whole ldl cholesterol to HDL ratio. Docs usually use this ratio of complete ldl cholesterol to HDL as a solution to gauge threat for coronary heart illness. A better ratio will increase the chance. Many elements contribute to the build-up of unhealthy ldl cholesterol and plaque within the physique that may result in an elevated threat for coronary heart illness. Smoking, consuming unhealthy fatty and fried meals, an individual’s weight, and never getting sufficient train can all contribute to your threat.

However different elements, together with your loved ones historical past, sure well being situations, and your intercourse additionally play a task. As well as, your genetics can affect your chance of creating larger LDL ldl cholesterol or decrease HDL, each of which may improve one’s threat for coronary heart illness. About 30 p.c of males and 10 p.c of females in the US have low HDL ldl cholesterol, in keeping with a report by the Centers for Disease Control and Prevention.

Going Deeper on HDL

23andMe gives a number of experiences that give prospects insights into completely different heart-related situations. As an illustration, there are experiences on kind 2 diabetes, familial hypercholesterolemia (an inherited type of excessive LDL ldl cholesterol), and TTR-related hereditary amyloidosis, a genetic situation related to cardiac and neurological issues.**

For many who wish to go a little bit deeper, we provide 23andMe+,* an annual membership with 10+ unique experiences and options delivered to you all year long. Amongst these experiences are a number of heart-related situations to discover. Together with experiences on coronary artery illness, hypertension, atrial fibrillation, triglycerides, and LDL ldl cholesterol, we not too long ago added a brand new report on HDL ldl cholesterol to 23andMe+. All are powered by 23andMe analysis.

This new report doesn’t diagnose low HDL ldl cholesterol. As a substitute, it estimates the chance of creating low HDL primarily based on a statistical mannequin that considers greater than 15,000 genetic markers related to creating low HDL. The mannequin additionally consists of ethnicity and intercourse to calculate an estimate. The information used within the mannequin comes from 23andMe prospects who consented to take part in analysis. 

Taking Motion

Understanding extra about your genetics is usually a good first step in studying about your possibilities for coronary heart illness. Keep in mind to speak together with your healthcare supplier earlier than making any main life-style modifications. That mentioned, sustaining a wholesome weight, consuming a weight loss program that’s low in saturated fats, and getting loads of train can go a great distance towards good coronary heart well being.

To study extra about 23andMe+ membership, go here.


*10+ experiences and options will probably be added yearly from January to December.

***23andMe well being predisposition experiences embrace each experiences that meet FDA necessities for genetic well being dangers and experiences that are primarily based on 23andMe analysis and haven’t been reviewed by the FDA. The check makes use of qualitative genotyping to detect choose clinically related variants within the genomic DNA of adults from saliva for the aim of reporting and deciphering genetic well being dangers. It isn’t meant to diagnose any illness. Your ethnicity could have an effect on the relevance of every report and the way your genetic well being threat outcomes are interpreted. Every genetic well being threat report describes if an individual has variants related to the next threat of creating a illness, however doesn’t describe an individual’s general threat of creating the illness. The check shouldn’t be meant to inform you something about your present state of well being, or for use to make medical selections, together with whether or not or not you need to take a drugs, how a lot of a drugs you need to take, or decide any remedy. For necessary data and limitations concerning every genetic well being threat report, go to 23andme.com/test-info/.

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